What is Gene Ontology?
Gene Ontology is a way of categorizing and understanding what we know about the molecular function, cellular component, and biological processes associated with our gene of interest. [1]
Molecular Function: Describes the specific activities carried out at the molecular level by gene products, either individually or as part of larger complexes. This includes actions such as catalytic activity and receptor binding, focusing solely on the functions these molecules perform, rather than the structures or complexes themselves.
Cellular Component: Refers to the specific locations within a cell where gene products are found and perform their functions. It focuses on aspects of cellular anatomy rather than processes, highlighting the different structures and areas where these gene products operate.
Biological Processes: Refers to a broad sequence of events comprising multiple molecular activities, such as signal transduction and neuronal activation. These processes encompass more than just individual pathways, involving complex interactions and activities at the cellular level.
Molecular Function: Describes the specific activities carried out at the molecular level by gene products, either individually or as part of larger complexes. This includes actions such as catalytic activity and receptor binding, focusing solely on the functions these molecules perform, rather than the structures or complexes themselves.
Cellular Component: Refers to the specific locations within a cell where gene products are found and perform their functions. It focuses on aspects of cellular anatomy rather than processes, highlighting the different structures and areas where these gene products operate.
Biological Processes: Refers to a broad sequence of events comprising multiple molecular activities, such as signal transduction and neuronal activation. These processes encompass more than just individual pathways, involving complex interactions and activities at the cellular level.
GO for HCRT
Molecular Function Cellular Component Biological Processes
•neuropeptide hormone activity
|
•perinuclear region of cytoplasm
|
•sleep
•regulation of neurotransmitter secretion •positive regulation of transmission of nerve impulse |
Discussion
HCRT is located in the perinuclear region of the cytoplasm and is used for neuropeptide hormone activity in the regulation of neurotransmitter secretion and positive regulation of transmission of nerve impulses. Through these mechanisms it is believed that HCRT is involved in circadian rhythm sleep disorders such as Narcolepsy Type 1. [2]
References
[1] Gene ontology overview. Gene Ontology Resource. (2024, April 9). https://geneontology.org/docs/ontology-documentation/
[2] InterProScan Search Result, HCRT. InterPro. (n.d.).
[2] InterProScan Search Result, HCRT. InterPro. (n.d.).
This page was produced as an assignment for Genetics 564, a capstone course at UW-Madison.