What are protein interactions?
The functional protein interactions of proteins contribute to all the known biological processes in an organism. Understanding the connections different proteins have to one another helps scientists understand how they contribute to biological function.[1] By connecting the gene ontology of proteins directly and indirectly using the STRING algorithm, we can understand how proteins affect one another in a living organism.[2]
Results
STRING analysis of HRCT in Homo sapiens and Danio rerio showed that the hypocretin signaling network was loosely associated with a gene network of circadian rhythm regulator genes. This is important as it shows that there is a known association and that it needs to be better studied in order to confirm how these protein interaction networks work together in the pathology of Narcolepsy Type 1.
References
[1] Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork P, Jensen LJ, Mering CV. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613. doi: 10.1093/nar/gky1131. PMID: 30476243; PMCID: PMC6323986.
[2] https://string-db.org/
[2] https://string-db.org/
This page was produced as an assignment for Genetics 564, a capstone course at UW-Madison.